ERN1 / IRE1

endoplasmic reticulum to nucleus signaling 1

The endoribonuclease IRE1/ERN1 encodes the ER-to-nucleus signaling 1 protein, a human homolog of the yeast Ire1 gene product. In S. cerevisiae, as well as in human, this ER transmembrane IRE serine/threonine protein kinase monitors the status of unfolded proteins inside the ER lumen in response to stress. Activation of ERN1 leads to oligomerization, autophosphorylation, and proteolytic cleavage. The kinase and nuclease domains are then transported into the nucleus to function as a site-specific endoribonuclease. ERN1 activates JNK and other chaperone genes in response to stress.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

ERN1 / IRE1 (9)

Application

SDS-PAGE (1)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (1)

His-GST (1)

His-GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Source

293T Cells (1)

Baculovirus (3)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

Biologically Active

Biologically active (1)

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Human ERN1 / IRE1 Protein (Recombinant His-GST, N-terminus) (Pro465-Leu977) - LS-G47849

Source:

Baculovirus

Tag:

His-GST, N-terminus

Application:

SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human ERN1/GST chimera consists of 750 amino acids and has a calculated molecular mass of 86 kDa. It migrates as an approximately 90 kDa band in SDS-PAGE under reducing conditions.

Price:

50 µg/$410

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Human ERN1 / IRE1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70861

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.6 kDa

Price:

20 µg/$1,107

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Human ERN1 / IRE1 Protein (Recombinant His-T7) (aa571-832) - LS-G24872

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human ERN1 / IRE1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88178

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.6 kDa

Price:

20 µg/$215

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Human ERN1 / IRE1 Protein (Recombinant GST, N-terminus) (aa401-500) - LS-G58488

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ERN1 / IRE1 Protein (Recombinant His-GST) (Pro465-Leu977) - LS-G97437

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

86 kDa

Price:

50 µg/$707

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Human ERN1 / IRE1 Protein (Recombinant) (Pro465-Leu977) - LS-G98573

Source:

Baculovirus

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

58.3 kDa

Price:

50 µg/$625

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ERN1 / IRE1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118592

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.6 kDa

Price:

100 µg/$710

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Human ERN1 / IRE1 Protein (Recombinant GST) (Full Length) - LS-G28385

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

33 kDa

Price:

10 µg/$479; 25 µg/$670

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