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ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
Gene Name: | excision repair cross-complementing rodent repair deficiency, complementation group 2 |
Synonyms: | ERCC2, COFS2, EM9, XPD, TFIIH p80, BTF2 p80, TTD, XPDC, CXPD, TFIIH 80 kDa subunit |
Target Sequences: | NM_000400 CAA36463.1 P18074 |
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