ERBB2 / HER2

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

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Products

ELISA Kits (23)

Type

Cell-Based (1)

Cell-Based Phosphorylation (4)

Custom (2)

Sandwich (15)

Sandwich CLIA (1)

Target

ERBB2 / HER2 (23)

Reactivity

Human (13)

Mouse (8)

Rat (8)

Chicken (1)

Dog (1)

Monkey (1)

Pig (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (7)

96-Well Strip Plate (15)

Publications

No (22)

Yes (1)

Sample Type

Adherent Cell Cultures (5)

Cell Culture Supernatants (3)

Cell Lysates (1)

Plasma (14)

Serum (14)

Tissue Homogenates (8)

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Human ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F5037

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$798

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Mouse/Human/Rat ERBB2 / HER2 (Cell-Based ELISA) ELISA Kit - LS-F2046

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse/Human/Rat Phospho-ERBB2 / HER2 (Tyr1248) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1527

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F5689

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.315 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$715

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Mouse/Human/Rat Phospho-ERBB2 / HER2 (Tyr877) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1528

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F77

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

8.19 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Pig ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F32151

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F24528

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$624

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Human ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F2667

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$699

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Rat ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F5857

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$750

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Human ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F11387

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

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Rat ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F11388

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F32946

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F32947

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human ERBB2 / HER2 (CLIA) ELISA Kit - LS-F30026

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Human ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F52658

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$897

Select

Chicken ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F43598

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$565

Select

Monkey ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F43599

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$565

Select

Human ERBB2 / HER2 (Sandwich ELISA) ELISA Kit - LS-F36878

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse ERBB2 / HER2 (Custom ELISA) ELISA Kit - LS-F18687

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$585

Select

Dog ERBB2 / HER2 (Custom ELISA) ELISA Kit - LS-F18688

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse/Human/Rat Phospho-ERBB2 / HER2 (Tyr1221, Tyr1222) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1526

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse/Human/Rat Phospho-ERBB2 / HER2 (Tyr1112) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1662

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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