ER Alpha / Estrogen Receptor

estrogen receptor 1

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.

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Products

Proteins (19)

Type

Over-Expression Lysate (8)

Recombinant (11)

Target

ER Alpha / Estrogen Receptor (19)

Product Group

SARS-CoV-2 Associated Proteins (19)

Publications

No (19)

Tag

6His, N-terminus (3)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-GST (2)

Myc-DDK (Flag) (11)

Species

Human (13)

Mouse (1)

Rat (1)

Source

293T Cells (4)

E. coli (5)

HEK 293 Cells (7)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (2)

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Human ER Alpha / Estrogen Receptor Protein (Recombinant 6His, N-terminus) (aa10-595) - LS-G57163

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human ER Alpha / Estrogen Receptor Protein (Recombinant 6His, N-terminus) (Met1-Gln116) - LS-G39541

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

14.38kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Human ER Alpha / Estrogen Receptor Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65565

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66 kDa

Price:

20 µg/$1,107

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Mouse ER Alpha / Estrogen Receptor Protein (Recombinant His-GST) (aa233-483) - LS-G24194

Source:

E. coli

Tag:

His-GST

Molecular Weight:

58.6 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human ER Alpha / Estrogen Receptor Protein (Recombinant GST) (Full Length) - LS-G28389

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

92.6 kDa

Price:

2 µg/$439

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Rat ER Alpha / Estrogen Receptor Protein (Recombinant His-GST) (aa248-484) - LS-G13314

Source:

E. coli

Tag:

His-GST

Molecular Weight:

59.0 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human ER Alpha / Estrogen Receptor Protein (Recombinant GST, N-terminus) (aa41-140) - LS-G58490

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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ER Alpha / Estrogen Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98931

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66 kDa

Price:

100 µg/$710

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Human ER Alpha / Estrogen Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75809

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66 kDa

Price:

20 µg/$215

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Human ER Alpha / Estrogen Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75810

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66 kDa

Price:

20 µg/$150

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Human ER Alpha / Estrogen Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75811

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66 kDa

Price:

20 µg/$150

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Human ER Alpha / Estrogen Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75812

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66 kDa

Price:

20 µg/$150

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Human ER Alpha / Estrogen Receptor Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65566

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66 kDa

Price:

20 µg/$1,107

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Human ER Alpha / Estrogen Receptor Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65567

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66 kDa

Price:

20 µg/$1,107

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ER Alpha / Estrogen Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124420

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66 kDa

Price:

100 µg/$494

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ER Alpha / Estrogen Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124421

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66 kDa

Price:

100 µg/$494

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ER Alpha / Estrogen Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124422

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66 kDa

Price:

100 µg/$494

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Human ER Alpha / Estrogen Receptor Protein (Recombinant His, N-Terminal) (Ser178-Met438) - LS-G24193

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

33.36 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human ER Alpha / Estrogen Receptor Protein (Recombinant 6His, N-terminus) (Met1-Gln116) - LS-G140154

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

14.4 kDa

Price:

10 µg/$317; 50 µg/$524

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