Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
Gene Name: | glutamyl-prolyl-tRNA synthetase |
Synonyms: | EPRS, GLNS, GLUPRORS, Glutamate tRNA ligase, Glutaminyl-tRNA synthetase, PIG32, Proline-tRNA ligase, Prolyl-tRNA synthetase, Proline tRNA ligase, EARS, PARS, QPRS |
Target Sequences: | NM_004446 NP_004437.2 P07814 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.