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Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Gene Name: | epoxide hydrolase 1, microsomal (xenobiotic) |
Family/Subfamily: | Protease , Serine S33 |
Synonyms: | EPHX1, Epoxide hydratase, Epoxide hydrolase, Epoxide hydrolase 1, HYL1, MEH, Microsomal epoxide hydrolase, EPHX, EPOX |
Target Sequences: | NM_000120 NP_000111.1 P07099 |
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