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EPHA7 / EPH Receptor A7

EPH receptor A7

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Gene Name: EPH receptor A7
Family/Subfamily: Protein Kinase , Ephrin Receptor
Synonyms: EPHA7, EHK-3, EK11, EPH homology kinase 3, Eph homology kinase-3, EPH receptor A7, EHK3, Ephrin type-A receptor 7, MDK1, Ebk, EPH-like kinase 11, HEK11
Target Sequences: NM_004440 NP_004431.1 Q15375

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Products
Proteins (13)
Over-Expression Lysate (2)
Recombinant (11)
EPHA7 / EPH Receptor A7 (13)
No (13)
6His, C-terminus (1)
DDK (Flag)-His, C-terminus (1)
DDK,C-terminus (1)
Fc (1)
GST (1)
GST, N-terminus (1)
His (2)
His,C-terminus (1)
His-GST (1)
Myc-DDK (Flag) (3)
Human (9)
Mouse (1)
Rat (2)
293T Cells (1)
Baculovirus (1)
HEK 293 Cells (3)
Human Cells (4)
Mammalian Cells (1)
Sf9 Cells (1)
Wheat Germ Extract (2)
Purified (4)
Low endotoxin level (6)
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Baculovirus
His-GST
Less than 1.0 EU/µg protein (determined by LAL method).
75.2 kDa
50 µg/$707
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
58.9 kDa
200 µg/$1,148
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
58.9 kDa
200 µg/$1,070
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
60.4 kDa
200 µg/$1,148
EPHA7 / EPH Receptor A7 Protein - Purified recombinant protein EPHA7 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
111.9 kDa
20 µg/$1,107
EPHA7 / EPH Receptor A7 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
EPHA7 / EPH Receptor A7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
111.9 kDa
20 µg/$215
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
60.19 kDa
10 µg/$277; 50 µg/$389
EPHA7 / EPH Receptor A7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
111.9 kDa
100 µg/$710
EPHA7 / EPH Receptor A7 Protein
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
62 kDa
20 µg/$1,107
EPHA7 / EPH Receptor A7 Protein
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Sf9 Cells
DDK,C-terminus
59 kDa
20 µg/$677
EPHA7 / EPH Receptor A7 Protein - 12.5% SDS-PAGE of human EPHA7 stained with Coomassie Blue
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Wheat Germ Extract
GST
56.32 kDa
10 µg/$479; 25 µg/$670
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
60.19kD
10 µg/$277; 50 µg/$395; 500 µg/$1,203; 1 mg/$1,627
Viewing 1-13 of 13 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).