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ENTPD6/CD39L2 exists a both a membrane form and as a secreted protein. ENTPD6, a nucleoside triphosphate diphosphohydrolase, preferentially hydrolyzes nucleoside diphosphates and is strongly activated in the presence of divalent cations. Circulating levels of nucleotides in the blood regulate a variety of physiological states including cardiac function, hormone secretion, immune responses, neurotransmission, and platelet aggregation. Expression of ENTPD6/CD39L2 is found predominantly in human heart myocytes and capillary endothelial cells and may be a mediator of platelet aggregation in the heart.
Gene Name: | ectonucleoside triphosphate diphosphohydrolase 6 (putative) |
Synonyms: | ENTPD6, CD39-like 2, CD39L2, DJ738P15.3, HCV-E2 binding protein 1, IL-6SAG, NTPDase-6, IL6ST2, CD39 antigen-like 2, NTPDase 6 |
Target Sequences: | NM_001247 NP_001238.2 O75354 |
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