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Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.
Gene Name: | ectonucleoside triphosphate diphosphohydrolase 4 |
Synonyms: | ENTPD4, KIAA0392, LALP70, LAP70, LYSAL1, NTPDase-4, Lysosomal apyrase-like 1, Uridine-diphosphatase, Golgi luminal UDPase, NTPDase 4, UDPase |
Target Sequences: | NM_004901 NP_004892.1 Q9Y227 |
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