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Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).
Gene Name: | F-box protein 43 |
Family/Subfamily: | F-Box |
Synonyms: | FBXO43, Early mitotic inhibitor 2, EMI2, Endogenous meiotic inhibitor 2, F-box protein 43, ERP1, F-box only protein 43, FBX43 |
Target Sequences: | Q4G163 Q4G163 |
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