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ELK1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14.
Gene Name: | ELK1, member of ETS oncogene family |
Family/Subfamily: | Transcription factor , ETS |
Synonyms: | ELK1, Elk1 transcription factor, ETS-like gene 1 |
Target Sequences: | NM_005229 NP_005220.2 P19419 |
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