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ELF5 is a member of an epithelium-specific subclass of the Ets transcription factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene Name: | E74-like factor 5 (ets domain transcription factor) |
Synonyms: | ELF5, ESE2, E74-like factor 5, ESE-2 |
Target Sequences: | NM_001422 NP_001413.1 Q9UKW6 |
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