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ELAVL3 / HUC

ELAV like neuron-specific RNA binding protein 3

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene Name: ELAV like neuron-specific RNA binding protein 3
Synonyms: ELAVL3, ELAV-like protein 3, Hu antigen C, HUC, Hu-antigen C, HUCL, PLE21
Target Sequences: NM_001420 NP_001411.2 Q14576

Publications (1)

1
Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis. Sandra Diaz-Garcia, Vivian I Ko, Sonia Vazquez-Sanchez, Ruth Chia, Olubankole Aladesuyi Arogundade, Maria J Rodriguez, Bryan J Traynor, Don Cleveland, John Ravits. Acta neuropathologica. 2021 December;142:985-1001. [Full Text Article] [PubMed:34618203] [PMC:PMC8568872] Related Antibodies: LS-C408905.

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Proteins (11)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (5)
Recombinant (5)
ELAVL3 / HUC (11)
No (11)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (2)
Myc-DDK (Flag) (5)
Human (9)
293T Cells (2)
E. coli (1)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Yeast (1)
Purified (1)
ELAVL3 / HUC Protein
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Yeast
6His, N-terminus
41.5 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
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HEK 293 Cells
His, N-Terminal
~40 kDa
100 µg/$298
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HEK 293 Cells
His, N-Terminal
~40 kDa
200 µl/$283
ELAVL3 / HUC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.7 kDa
100 µg/$494
ELAVL3 / HUC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.4 kDa
100 µg/$494
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E. coli
His
43.6 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ELAVL3 / HUC Protein - 12.5% SDS-PAGE of human ELAVL3 stained with Coomassie Blue
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Wheat Germ Extract
GST
66.11 kDa
2 µg/$439
ELAVL3 / HUC Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ELAVL3 / HUC Protein - Purified recombinant protein ELAVL3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
39.4 kDa
20 µg/$1,107
ELAVL3 / HUC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.4 kDa
20 µg/$150
ELAVL3 / HUC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
38.7 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).