Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
EIF4G1 / EIF4G is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.
Gene Name: | eukaryotic translation initiation factor 4 gamma, 1 |
Synonyms: | EIF4G1, EIF4-gamma, EIF-4-gamma 1, EIF-4G1, EIF4F, EIF4G, p220, PARK18, EIF-4G 1, EIF4GI |
Target Sequences: | NM_004953 NP_004944.3 Q04637 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.