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EIF4EBP1 / 4EBP1

eukaryotic translation initiation factor 4E binding protein 1

EIF4EBP1 / 4EBP1 is one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Gene Name: eukaryotic translation initiation factor 4E binding protein 1
Synonyms: EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, EIF4E-binding protein 1
Target Sequences: NM_004095 NP_004086.1 Q13541

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Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
EIF4EBP1 / 4EBP1 (9)
No (9)
6His, N-terminus (2)
GST (1)
His (4)
Myc-DDK (Flag) (2)
Human (6)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (6)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (2)
EIF4EBP1 / 4EBP1 Protein
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E. coli
His
100 µg/$317; 500 µg/$526; 20 µg/$245
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.74kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
EIF4EBP1 / 4EBP1 Protein - 12.5% SDS-PAGE of human EIF4EBP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
38.72 kDa
10 µg/$479; 25 µg/$670
EIF4EBP1 / 4EBP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
12.4 kDa
20 µg/$150
EIF4EBP1 / 4EBP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
12.4 kDa
100 µg/$494
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.7 kDa
10 µg/$288; 50 µg/$436
Select
E. coli
His
13.7 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Select
E. coli
His
13.7 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Select
E. coli
His
13.9 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).