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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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EIF3M / PCID1
eukaryotic translation initiation factor 3, subunit M
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).
| Gene Name: | eukaryotic translation initiation factor 3, subunit M |
| Synonyms: | EIF3M, B5, B5 receptor, Dendritic cell protein, GA17, HFLB5, Fetal lung protein B5, Hfl-B5, TANGO7, PCID1 |
| Target Sequences: | NM_006360 NP_006351.2 Q7L2H7 |
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