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Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Gene Name: | eukaryotic translation initiation factor 3, subunit A |
Synonyms: | EIF3A, Centrosomin homolog, Cytoplasmic protein p167, EIF3S10, EIF3 p167, EIF3 p180, EIF-3-theta, EIF3 p185, EIF3, p180 subunit, KIAA0139, p167, p180, p185, TIF32, EIF3, EIF3-p170, EIF3-theta |
Target Sequences: | NM_003750 NP_003741.1 Q14152 |
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