EIF2S1

eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

EIF2 is a translation initiation factor that catalyzes the first regulated step of protein synthesis, promoting the binding of the initiator tRNA to 40s ribosomal subunits. eIF2 is composed of 3 non identical subunits, alpha, beta and gamma. Binding occurs as a ternary complex of methionyl-tRNA, eIF2 and GTP. The rate of complex formation is modulated by the phosphorylation state of eIF2alpha. Phosphorylation of eIF2alpha has been shown to occur in response to heat shock and hypoxic stress. Once eIF2alpha is phosphorylated, the initiation of protein synthesis is inhibited. Expression of eIF-2alpha has been shown to increase in melanoma and colon carcinoma.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

EIF2S1 (6)

Publications

No (6)

Tag

GST (1)

His (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human EIF2S1 Protein (Recombinant His) - LS-G810

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human EIF2S1 Protein (Recombinant GST) (Full Length) - LS-G28315

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

60.39 kDa

Price:

10 µg/$479; 25 µg/$670

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Human EIF2S1 Protein (Recombinant His-T7, N-terminus) (Met1-Thr239) - LS-G133328

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

31.7kDa

Price:

10 µg/$263; 50 µg/$343; 200 µg/$662; 100 µg/$530; 1 mg/$1,657; 500 µg/$1,242; 5 mg/$2,600; 2 mg/$1,832

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EIF2S1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100205

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

100 µg/$494

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Human EIF2S1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75840

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

20 µg/$150

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Human EIF2S1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65581

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

20 µg/$1,107

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