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EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF2 is a translation initiation factor that catalyzes the first regulated step of protein synthesis, promoting the binding of the initiator tRNA to 40s ribosomal subunits. eIF2 is composed of 3 non identical subunits, alpha, beta and gamma. Binding occurs as a ternary complex of methionyl-tRNA, eIF2 and GTP. The rate of complex formation is modulated by the phosphorylation state of eIF2alpha. Phosphorylation of eIF2alpha has been shown to occur in response to heat shock and hypoxic stress. Once eIF2alpha is phosphorylated, the initiation of protein synthesis is inhibited. Expression of eIF-2alpha has been shown to increase in melanoma and colon carcinoma.
| Gene Name: | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa |
| Synonyms: | EIF2S1, EIF-2-alpha, EIF-2alpha, EIF2 alpha, EIF2, EIF-2, EIF-2A |
| Target Sequences: | NM_004094 NP_004085.1 P05198 |
Publications (1)
1
Viral double-stranded RNAs from vaccinia virus early or intermediate gene transcripts possess PKR activating function, resulting in NF-kappaB activation, when the K1 protein is absent or mutated. Willis KL, Langland JO, Shisler JL. The Journal of biological chemistry. 2011 286:7765-78. (WB)
[PubMed:21183678]
[PMC:PMC3048664]
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Antibodies
(65)
Proteins
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(2)
Type
Cell-Based
(1)
Cell-Based Phosphorylation
(1)
Over-Expression Lysate
(2)
Primary
(65)
Recombinant
(4)
Target
EIF2S1
(73)
Reactivity
Human
(62)
Mouse
(43)
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(37)
Bat
(7)
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(9)
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(8)
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(6)
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(7)
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(8)
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(17)
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(43)
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(45)
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(3)
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(33)
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(14)
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(1)
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(1)
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monoclonal mc
(20)
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(45)
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11C1031
(1)
1763CT102.71.17
(1)
3H12-C11
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AT5E10
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EIF2S1A2B8
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30-110 aa
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aa123-137
(1)
aa21-70
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(1)
pS51
(1)
pSer49
(1)
pSer52
(1)
Publications
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(73)
Sample Type
Adherent Cell Cultures
(2)
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GST
(1)
His
(1)
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(1)
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(3)
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(5)
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(2)
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(2)
EIF2S1 Rabbit anti-Human Polyclonal (pSer51) Antibody
Chicken, Zebrafish, Pig, Bovine, Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
30 µl/$263; 50 µl/$279; 100 µl/$315; 200 µl/$379
EIF2S1 Rabbit anti-Human Polyclonal (pS51) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
2 Plates/$668
EIF2S1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
EIF2S1 Mouse anti-Human Monoclonal (AT5E10) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
EIF2S1 Mouse anti-Human Monoclonal (EIF2S1A2B8) Antibody
Mouse, Rat, Human
DB, Flo, ICC, IF, WB
Unconjugated
100 µg/$486
EIF2S1 Rabbit anti-Human Polyclonal (aa21-70) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
EIF2S1 Rabbit anti-Human Polyclonal (aa60-89) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
EIF2S1 Rabbit anti-Human Monoclonal (11C1031) Antibody
Mouse, Rat, Human, Monkey
IHC, IP, WB
Unconjugated
20 µl/$483; 100 µl/$763
EIF2S1 Mouse anti-Human Monoclonal (OTI3H4) Antibody
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
EIF2S1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3H4) Antibody
Dog, Rat, Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
EIF2S1 Rabbit anti-Human Polyclonal (pSer51) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
EIF2S1 Mouse anti-Human Monoclonal (OTI5D10) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
EIF2S1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
EIF2S1 Rabbit anti-Human Polyclonal (pSer51) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
![EIF2S1 Antibody - Immunofluorescence of monoclonal antibody to EIF2S1 on HeLa cell. [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/eif2s1-antibody-clone-3h12-c11-ls-c197117/144692_4883318.jpg)
EIF2S1 Mouse anti-Human Monoclonal (3H12-C11) Antibody
Human
ELISA, IF, RNAi, WB
Unconjugated
100 µg/$423
EIF2S1 Rabbit anti-Human Polyclonal (pSer52) Antibody
Mouse, Human
WB
Unconjugated
10 Blots/$842
EIF2S1 Rabbit anti-Human Polyclonal (aa71-120) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
EIF2S1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Pig, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
EIF2S1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Flo, IF, IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
EIF2S1 Rabbit anti-Human Polyclonal (aa60-89) (Biotin) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
EIF2S1 Rabbit anti-Human Polyclonal (aa60-89) (FITC) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
EIF2S1 Rabbit anti-Human Polyclonal (aa60-89) (PE) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
EIF2S1 Rabbit anti-Human Polyclonal (aa60-89) (APC) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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