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EIF2AK3 / PERK
eukaryotic translation initiation factor 2-alpha kinase 3
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
| Gene Name: | eukaryotic translation initiation factor 2-alpha kinase 3 |
| Family/Subfamily: | Protein Kinase , Translational Control Kinase |
| Synonyms: | EIF2AK3, HRI, HsPEK, Pancreatic eIF2-alpha kinase, PEK, PERK, PKR-like ER kinase, WRS |
| Target Sequences: | NM_004836 NP_004827.4 Q9NZJ5 |
Publications (3)
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