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EIF2AK3 / PERK
eukaryotic translation initiation factor 2-alpha kinase 3
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
| Gene Name: | eukaryotic translation initiation factor 2-alpha kinase 3 |
| Family/Subfamily: | Protein Kinase , Translational Control Kinase |
| Synonyms: | EIF2AK3, HRI, HsPEK, Pancreatic eIF2-alpha kinase, PEK, PERK, PKR-like ER kinase, WRS |
| Target Sequences: | NM_004836 NP_004827.4 Q9NZJ5 |
Publications (3)
1
Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2a-dependent translational attenuation and insulin biosynthesis in pancreatic ß cells. Akai R, Hosoda A, Yoshino M, Iwawaki T. Genes to cells : devoted to molecular & cellular mechanisms. 2015 November;20:871-86. [Full Text Article]
[PubMed:26314560]
2
Linagliptin and Vitamin D3 Synergistically Rescue Testicular Steroidogenesis and Spermatogenesis in Cisplatin-Exposed Rats: The Crosstalk of Endoplasmic Reticulum Stress with NF-?B/iNOS Activation. Rania A Elrashidy, Esraa M Zakaria, Asmaa M Elmaghraby, Rasha E M Abd El Aziz, Ranya M Abdelgalil, Rehab M Megahed, Asmaa A Elshiech, Doaa E A Salama, Samah E Ibrahim. Molecules (Basel, Switzerland). 2022 October;27: [Full Text Article]
[PubMed:36364125]
[PMC:PMC9657441]
3
Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells. Vong CT, Tseng HH, Kwan YW, Lee SM, Hoi MP. Frontiers in pharmacology. 2016 7:67. (WB; Human)
[Full Text Article]
[PubMed:27047382]
[PMC:PMC4800184]
Related Antibodies: LS-C118320.
☰ Filters
Products
ELISA Kits
(12)
Type
Cell-Based
(1)
Custom
(2)
Sandwich
(8)
Sandwich CLIA
(1)
Target
EIF2AK3 / PERK
(12)
Reactivity
Human
(5)
Mouse
(4)
Rat
(5)
Format
12 x 8-Well Microstrips
(1)
96-Well Microplate
(3)
96-Well Strip Plate
(8)
Publications
No
(11)
Yes
(1)
Sample Type
Adherent Cell Cultures
(1)
Cell Culture Supernatants
(1)
Plasma
(8)
Serum
(8)
Tissue Homogenates
(4)
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
Sandwich
96-Well Strip Plate
Rat
46.875 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$748
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
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