EHMT1

euchromatic histone-lysine N-methyltransferase 1

Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

EHMT1 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human EHMT1 Protein (Recombinant GST, N-terminus) (Full Length) - LS-G35293

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

113.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human EHMT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85208

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

141.9 kDa

Price:

20 µg/$215

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EHMT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101910

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

141.9 kDa

Price:

100 µg/$710

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