EGLN2 / PHD1

egl-9 family hypoxia-inducible factor 2

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappaB activation in hypoxic conditions. Target proteins are preferencially recognized via a LXXLAP motif.

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Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

EGLN2 / PHD1 (8)

Publications

No (8)

Tag

GST (1)

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human EGLN2 / PHD1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71753

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

20 µg/$1,107

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Human EGLN2 / PHD1 Protein (Recombinant His) (aa283-407) - LS-G20693

Source:

E. coli

Tag:

His

Molecular Weight:

18.2 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human EGLN2 / PHD1 Protein (Recombinant GST) (Full Length) - LS-G36123

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.51 kDa

Price:

10 µg/$479; 25 µg/$670

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EGLN2 / PHD1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102165

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

100 µg/$494

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Human EGLN2 / PHD1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90548

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

20 µg/$150

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Human EGLN2 / PHD1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90551

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

20 µg/$150

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EGLN2 / PHD1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107754

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

100 µg/$494

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Human EGLN2 / PHD1 Protein (Recombinant His, N-Terminal) - LS-G144139

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

43.5 kDa

Price:

50 µg/$419

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