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One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. EF is a calmodulin-dependent adenylyl cyclase that, when associated with PA, causes edema. EF is not toxic by itself and it is required for the survival of germinated spores within macrophages at the early stages of infection. Provokes dramatic elevation of intracellular cAMP levels in the host.
Gene Name: | calmodulin-sensitive adenylate cyclase |
Family/Subfamily: | Toxin |
Synonyms: | cya, Edema Factor, EF |
Target Sequences: | P40136 P40136 |
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