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EDN2 / Endothelin 2 is a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants.
Gene Name: | endothelin 2 |
Synonyms: | EDN2, Endothelin-2, ET2, ET-2, Endothelin 2, Preproendothelin 2, PPET2, Preproendothelin-2 |
Target Sequences: | BC034393 NP_001947.1 P20800 |
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