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EDN1 / Endothelin 1

endothelin 1

EDN1 / Endothelin 1 is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: endothelin 1
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: EDN1, Endothelin 1, Endothelin-1, ET1, Preproendothelin-1, PPET1, HDLCQ7
Target Sequences: NM_001955 NP_001946.3 P05305

Publications (2)

1
Estrogen and progesterone regulate expression of the endothelins in the rhesus macaque endometrium. Keator CS, Mah K, Ohm L, Slayden OD. Human reproduction (Oxford, England). 2011 26:1715-28. (IHC-Fr; Monkey) [Full Text Article] [PubMed:21505040] [PMC:PMC3113504] Related Antibodies: LS-C11319.
2
B-lymphocyte-intrinsic and -extrinsic defects in secretory immunoglobulin A production in the neural crest-conditional deletion of endothelin receptor B model of Hirschsprung-associated enterocolitis. Giuliana Medrano, Frederic Cailleux, Peihong Guan, Korah Kuruvilla, Amanda J Barlow-Anacker, Ankush Gosain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 June;33:7615-7624. [Full Text Article] [PubMed:30908942] [PMC:PMC6529339]

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Products
Proteins (15)
Over-Expression Lysate (4)
Recombinant (11)
EDN1 / Endothelin 1 (15)
No (15)
6His, N-terminus (1)
GST (2)
GST, N-terminus (1)
His (4)
His, N-Terminal (2)
Myc-DDK (Flag) (5)
Human (8)
Mouse (2)
Pig (1)
Rat (2)
293T Cells (2)
E. coli (8)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (1)
EDN1 / Endothelin 1 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
19 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 250 µg/$518; 500 µg/$949
EDN1 / Endothelin 1 Protein - Recombinant Endothelin 1 By SDS-PAGE
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E. coli
His
5.8 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
EDN1 / Endothelin 1 Protein - Purified recombinant protein EDN1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
22.4 kDa
20 µg/$1,107
EDN1 / Endothelin 1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
EDN1 / Endothelin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
24.41 kDa
100 µg/$494
Select
293T Cells
Myc-DDK (Flag)
24.41 kDa
20 µg/$150
EDN1 / Endothelin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
24.8 kDa
20 µg/$150
EDN1 / Endothelin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
24.8 kDa
100 µg/$494
Select
E. coli
194 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
21.45 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Select
E. coli
GST
29.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
EDN1 / Endothelin 1 Protein - 12.5% SDS-PAGE of human EDN1 stained with Coomassie Blue
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Wheat Germ Extract
GST
50.8 kDa
2 µg/$439
EDN1 / Endothelin 1 Protein - Active Endothelin 1 (EDN1) by WB
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E. coli
His, N-Terminal
19kDa
10 µg/$347; 50 µg/$852; 200 µg/$1,493; 100 µg/$1,270; 1 mg/$2,803; 500 µg/$2,298; 5 mg/$5,951; 2 mg/$3,175
EDN1 / Endothelin 1 Protein - Recombinant Endothelin 1 By SDS-PAGE
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E. coli
His
18.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
EDN1 / Endothelin 1 Protein - Recombinant Endothelin 1 By SDS-PAGE
Select
E. coli
His, N-Terminal
21.0 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Select
E. coli
His
19.1 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).