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EDEM1 / EDEM

ER degradation enhancer, mannosidase alpha-like 1

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity.

Gene Name: ER degradation enhancer, mannosidase alpha-like 1
Synonyms: EDEM1, EDEM, KIAA0212
Target Sequences: AX210604

Publications (1)

1
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Davy Vanhoutte , Tobias G Schips , Alexander Vo, Kelly M Grimes, Tanya A Baldwin, Matthew J Brody, Federica Accornero, Michelle A Sargent, Jeffery D Molkentin. Nature communications. 2021 June;12:3928. [Full Text Article] [PubMed:34168130] [PMC:PMC8225674] Related Antibodies: LS-C80983.

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Antibodies (15)
Primary (15)
EDEM1 / EDEM (15)
Human (15)
Mouse (8)
Rat (2)
Bovine (4)
Chimpanzee (3)
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ELISA (8)
Peptide-ELISA (1)
rabbit (9)
mouse (6)
IgG (5)
IgG2a,k (6)
monoclonal mc (6)
polyclonal pc (9)
APC Conjugated (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (7)
aa146-195 (4)
C-Terminus (1)
Internal (1)
aa559-656 (1)
No (14)
Yes (1)
EDEM1 / EDEM Antibody - Western blot analysis of EDEM1 expression in HEK293T (A); Raw264.7 (B); PC12 (C) whole cell lysates.
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EDEM1 / EDEM Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human, Monkey
WB
Unconjugated
100 µl/$299
EDEM1 / EDEM Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EDEM1 / EDEM Rabbit anti-Human Polyclonal (aa146-195) Antibody
Human
WB
Unconjugated
100 µl/$424
EDEM1 / EDEM Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EDEM1 / EDEM Rabbit anti-Human Polyclonal (aa146-195) (HRP) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Hamster, Pig, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$469
EDEM1 / EDEM Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EDEM1 / EDEM Rabbit anti-Human Polyclonal (aa146-195) (Biotin) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Hamster, Pig, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
EDEM1 / EDEM Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EDEM1 / EDEM Rabbit anti-Human Polyclonal (aa146-195) (FITC) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Hamster, Pig, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
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EDEM1 / EDEM Mouse anti-Human Monoclonal (aa559-656) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
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EDEM1 / EDEM Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
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EDEM1 / EDEM Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
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EDEM1 / EDEM Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
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EDEM1 / EDEM Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
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EDEM1 / EDEM Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
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EDEM1 / EDEM Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
ELISA, WB
Unconjugated
0.1 mg/$379
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EDEM1 / EDEM Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
EDEM1 / EDEM Antibody - Western blot analysis of EDEM1 using NIH-3T3 whole cells lysates
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EDEM1 / EDEM Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
EDEM1 / EDEM Antibody - Western blot of EDEM1 antibody at 1:500 dilution. Lane 1: HEK293T whole cell lysate. Lane 2: Raw264.7 whole cell lysate. Lane 3: PC12 whole cell lysate.
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EDEM1 / EDEM Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).