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Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity.
Gene Name: | ER degradation enhancer, mannosidase alpha-like 1 |
Synonyms: | EDEM1, EDEM, KIAA0212 |
Target Sequences: | AX210604 |
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