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EDAR is a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
Gene Name: | ectodysplasin A receptor |
Synonyms: | EDAR, Ectodysplasin-A receptor, ED1R, EDA-A1 receptor, EDA1R, DL, Downless, mouse, homolog of, ED3, EDA3, ECTD10A, ECTD10B, Ectodysplasin A receptor, ED5, Downless homolog, Ectodermal dysplasia receptor, EDA-A1R, HRM1 |
Target Sequences: | NM_022336 NP_071731.1 Q9UNE0 |
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