ECT2

epithelial cell transforming sequence 2 oncogene

Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

ECT2 (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human ECT2 Protein (Recombinant His, N-Terminal) (aa453-647) - LS-G14924

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

23.8 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human ECT2 Protein (Recombinant GST, N-terminus) (aa46-145) - LS-G58401

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ECT2 Protein (Recombinant His) (aa166-348) - LS-G14922

Source:

E. coli

Tag:

His

Molecular Weight:

22.8 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human ECT2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90797

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.9 kDa

Price:

20 µg/$150

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ECT2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111989

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.9 kDa

Price:

100 µg/$494

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Mouse ECT2 Protein (Recombinant His-GST, N-terminus) (Leu672-Leu905) - LS-G133247

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

56.2kDa

Price:

10 µg/$279; 50 µg/$432; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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