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EBI3 / IL-27B

Epstein-Barr virus induced 3

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

Gene Name: Epstein-Barr virus induced 3
Synonyms: EBI3, Epstein-Barr virus induced 3, IL-27 subunit beta, IL27 subunit, IL27B, Interleukin-27 subunit beta, IL-27B, Cytokine receptor, EBV-induced gene 3 protein, IL35 subunit
Target Sequences: NM_005755 NP_005746.2 Q14213

Publications (2)

1
IL-35 mitigates murine acute graft-versus-host disease with retention of graft-versus-leukemia effects. Liu Y, Wu Y, Wang Y, Cai Y, Hu B, Bao G, Fang H, Zhao L, Ma S, Cheng Q, Song Y, Liu Y, Zhu Z, Chang H, Yu X, Sun A, Zhang Y, Vignali DA, Wu D, Liu H. Leukemia. 2015 29:939-46. (IHC; Mouse) [Full Text Article] [PubMed:25363669] [PMC:PMC4391991] Related Antibodies: LS-B5764.
2
Human neutrophils activated by TLR8 agonists, with or without IFN?, synthesize and release EBI3, but not IL-12, IL-27, IL-35, or IL-39. Marco A Cassatella, Elisa Gardiman, Fabio Arruda-Silva, Francisco Bianchetto-Aguilera, Sara Gasperini, Mattia Bugatti, William Vermi, Frederique Larousserie, Odile Devergne, Nicola Tamassia. Journal of leukocyte biology. 2020 November;108:1515-1526. [Full Text Article] [PubMed:32480433] Related Antibodies: LS-C314301.

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ELISA Kits (7)
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EBI3 / IL-27B (7)
Human (4)
Mouse (3)
96-Well Strip Plate (7)
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Cell Lysates (1)
Plasma (7)
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Tissue Homogenates (4)
EBI3 / IL-27B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
EBI3 / IL-27B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
EBI3 / IL-27B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$748
EBI3 / IL-27B ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
13.72 - 10000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$871
EBI3 / IL-27B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
EBI3 / IL-27B ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
2.74 - 2000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$851
EBI3 / IL-27B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$897
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).