EAR2 / NR2F6

nuclear receptor subfamily 2, group F, member 6

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).

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Products

ELISA Kits (8)

Type

Cell-Based (1)

Sandwich (7)

Target

EAR2 / NR2F6 (8)

Reactivity

Human (3)

Mouse (1)

Rat (1)

Chicken (1)

Guinea pig (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (7)

Publications

No (8)

Sample Type

Adherent Cell Cultures (1)

Plasma (2)

Serum (2)

Tissue Homogenates (1)

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Human EAR2 / NR2F6 (Sandwich ELISA) ELISA Kit - LS-F36138

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse/Human/Rat EAR2 / NR2F6 (Cell-Based ELISA) ELISA Kit - LS-F3054

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Guinea pig EAR2 / NR2F6 (Sandwich ELISA) ELISA Kit - LS-F43546

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Chicken EAR2 / NR2F6 (Sandwich ELISA) ELISA Kit - LS-F43547

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Monkey EAR2 / NR2F6 (Sandwich ELISA) ELISA Kit - LS-F43549

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Porcine EAR2 / NR2F6 (Sandwich ELISA) ELISA Kit - LS-F43550

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Rabbit EAR2 / NR2F6 (Sandwich ELISA) ELISA Kit - LS-F43551

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Human EAR2 / NR2F6 (Sandwich ELISA) ELISA Kit - LS-F49210

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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