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May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.
Gene Name: | E4F transcription factor 1 |
Synonyms: | E4F1, E4F, E4F transcription factor 1, p50E4F, Transcription factor E4F1, Transcription factor E4F, p120E4F, p120e4f transcription factor |
Target Sequences: | NM_004424 NP_004415.3 Q66K89 |
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