DYRK / DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

DYRK / DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

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Products

ELISA Kits (3)

Type

Cell-Based (1)

Sandwich (2)

Target

DYRK / DYRK1A (3)

Reactivity

Human (2)

Mouse (2)

Rat (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (2)

Publications

No (2)

Yes (1)

Sample Type

Adherent Cell Cultures (1)

Cell Culture Supernatants (1)

Cell Lysates (1)

Tissue Homogenates (2)

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Mouse DYRK / DYRK1A (Sandwich ELISA) ELISA Kit - LS-F7258

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$748

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Human DYRK / DYRK1A (Sandwich ELISA) ELISA Kit - LS-F8931

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$730

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Mouse/Human/Rat DYRK / DYRK1A (Cell-Based ELISA) ELISA Kit - LS-F3186

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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