Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
DYRK / DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK / DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
| Gene Name: | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
| Family/Subfamily: | Protein Kinase , MNB/DYRK |
| Synonyms: | DYRK1A, DYRK1, DYRK, HMNB, HP86, MNB, MNB/DYRK protein kinase, MRD7, MNBH, Serine/threonine kinase MNB, Yak1-related kinase |
| Target Sequences: | NM_001396 NP_001387.2 Q13627 |
Publications (1)
1
Comparative analysis of the DYRK1A-SRSF6-TNNT2 pathway in myocardial tissue from individuals with and without Down syndrome. Adolfo Quiñones-Lombraña, Javier G Blanco. Experimental and molecular pathology. 2019 Oct;;110:104268. [Full Text Article]
[PubMed:31201803]
[PMC:PMC6754281]
☰ Filters
Products
Antibodies
(52)
Proteins
(6)
ELISA Kits
(3)
Type
Cell-Based
(1)
Over-Expression Lysate
(2)
Primary
(52)
Recombinant
(4)
Sandwich
(2)
Target
DYRK / DYRK1A
(61)
Reactivity
Human
(52)
Mouse
(28)
Rat
(20)
Bat
(6)
Bovine
(6)
Chicken
(3)
Chimpanzee
(3)
Dog
(3)
Gibbon
(6)
Guinea pig
(6)
Horse
(6)
Monkey
(6)
Pig
(6)
Rabbit
(7)
Xenopus
(3)
Application
IHC
(9)
IHC-P
(6)
WB
(52)
ELISA
(25)
ICC
(2)
IF
(6)
IP
(2)
Peptide-ELISA
(3)
Host
rabbit
(50)
mouse
(2)
Product Group
IHCPlus
(1)
Isotype
IgG
(28)
IgG2b,k
(1)
Clonality
monoclonal mc
(2)
polyclonal pc
(50)
Clone
7D10
(1)
Format
96-Well Microplate
(1)
96-Well Strip Plate
(2)
APC
(1)
APC Conjugated
(4)
Azide-free
(3)
Biotin Conjugated
(6)
Cy3 Conjugated
(1)
Cy7 Conjugated
(1)
FITC Conjugated
(6)
HRP Conjugated
(6)
PE Conjugated
(4)
Unconjugated
(24)
Epitope
aa16-300
(8)
aa107-136
(7)
aa718-745
(7)
aa389-418
(6)
aa107-156
(4)
aa22-71
(4)
40-120 aa, N-terminal
(1)
Gln39
(1)
N-Terminus
(1)
aa21-70
(1)
aa25-50
(1)
aa674-763
(1)
aa713-763
(1)
Publications
No
(60)
Yes
(1)
Sample Type
Adherent Cell Cultures
(1)
Cell Culture Supernatants
(1)
Cell Lysates
(1)
Tissue Homogenates
(2)
Tag
DDK,C-terminus
(1)
GST, N-terminus
(1)
His
(1)
His-T7
(1)
Myc-DDK (Flag)
(2)
Species
Human
(5)
Source
293T Cells
(1)
E. coli
(2)
HEK 293 Cells
(1)
Sf9 Cells
(1)
Wheat Germ Extract
(1)
Purification
Purified
(1)
DYRK / DYRK1A Rabbit anti-Mouse Polyclonal (aa22-71) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
50 µl/$460
DYRK / DYRK1A Rabbit anti-Mouse Polyclonal (aa22-71) (HRP) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
DYRK / DYRK1A Rabbit anti-Mouse Polyclonal (aa22-71) (Biotin) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
DYRK / DYRK1A Rabbit anti-Mouse Polyclonal (aa22-71) (FITC) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
DYRK / DYRK1A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351
DYRK / DYRK1A Rabbit anti-Human Polyclonal (aa107-136) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$748
DYRK / DYRK1A Mouse anti-Human Monoclonal (7D10) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$423
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$730
DYRK / DYRK1A Rabbit anti-Human Polyclonal (aa25-50) Antibody
Human
IP, WB
Unconjugated
100 µl/$467
DYRK / DYRK1A Rabbit anti-Human Polyclonal (Gln39) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
DYRK / DYRK1A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
DYRK / DYRK1A Rabbit anti-Human Polyclonal (40-120 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
DYRK / DYRK1A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
DYRK / DYRK1A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, WB
Unconjugated
0.1 mg/$460
DYRK / DYRK1A Rabbit anti-Human Polyclonal (aa21-70) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
DYRK / DYRK1A Rabbit anti-Mouse Polyclonal (aa718-745) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
DYRK / DYRK1A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
DYRK / DYRK1A Mouse anti-Human Monoclonal (aa674-763) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$680
DYRK / DYRK1A Rabbit anti-Human Polyclonal (aa389-418) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
DYRK / DYRK1A Rabbit anti-Human Polyclonal (aa107-136) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
DYRK / DYRK1A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µl/$357
DYRK / DYRK1A Rabbit anti-Rat Polyclonal Antibody
Rat
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
DYRK / DYRK1A Rabbit anti-Human Polyclonal (aa713-763) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
DYRK / DYRK1A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Viewing 1-25
of 61
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
