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Dynactin 3 / DCTN3

Dynactin 3 (p22)

Dynactin 3 / DCTN3 is the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants.

Gene Name: Dynactin 3 (p22)
Synonyms: DCTN3, DCTN-22, Dynactin 3, p22, DCTN22, Dynactin 3 (p22), Dynactin light chain, Dynactin subunit 3
Target Sequences: NM_007234 NP_009165.1 O75935

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Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
Dynactin 3 / DCTN3 (7)
No (7)
GST (1)
His-SUMO (1)
Myc-DDK (Flag) (5)
Human (5)
293T Cells (2)
E. coli (1)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (1)
Dynactin 3 / DCTN3 Protein - 12.5% SDS-PAGE of human DCTN3 stained with Coomassie Blue
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Wheat Germ Extract
GST
44.88 kDa
10 µg/$479; 25 µg/$670
Dynactin 3 / DCTN3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$150
Dynactin 3 / DCTN3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
19.3 kDa
20 µg/$150
Dynactin 3 / DCTN3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
19.3 kDa
100 µg/$494
Dynactin 3 / DCTN3 Protein - Purified recombinant protein DCTN3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$1,107
Dynactin 3 / DCTN3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
100 µg/$494
Dynactin 3 / DCTN3 Protein
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E. coli
His-SUMO
35.3 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).