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Dynactin 3 / DCTN3
Dynactin 3 (p22)
Dynactin 3 / DCTN3 is the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants.
| Gene Name: | Dynactin 3 (p22) |
| Synonyms: | DCTN3, DCTN-22, Dynactin 3, p22, DCTN22, Dynactin 3 (p22), Dynactin light chain, Dynactin subunit 3 |
| Target Sequences: | NM_007234 NP_009165.1 O75935 |
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