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Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Gene Name: | dishevelled segment polarity protein 1 |
Synonyms: | DVL1, DVL, DVL1L1, DSH homolog 1, Dishevelled, Dishevelled-1 |
Target Sequences: | NM_004421 NP_004412.2 O14640 |
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