DUSP1 / MKP1

dual specificity phosphatase 1

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

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Products

ELISA Kits (7)

Type

Cell-Based (1)

Custom (2)

Sandwich (4)

Target

DUSP1 / MKP1 (7)

Reactivity

Human (4)

Mouse (2)

Rat (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (6)

Publications

No (7)

Sample Type

Adherent Cell Cultures (1)

Plasma (4)

Serum (4)

Tissue Homogenates (3)

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Human DUSP1 / MKP1 (Sandwich ELISA) ELISA Kit - LS-F32916

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human DUSP1 / MKP1 (Sandwich ELISA) ELISA Kit - LS-F7749

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$730

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Rat DUSP1 / MKP1 (Custom ELISA) ELISA Kit - LS-F20609

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Mouse DUSP1 / MKP1 (Custom ELISA) ELISA Kit - LS-F20608

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Mouse DUSP1 / MKP1 (Sandwich ELISA) ELISA Kit - LS-F8042

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$748

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Human DUSP1 / MKP1 (Cell-Based ELISA) ELISA Kit - LS-F2152

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Human DUSP1 / MKP1 (Sandwich ELISA) ELISA Kit - LS-F11333

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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