Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
Gene Name: | desmoplakin |
Synonyms: | DSP, Apeg-1, Desmoplakin II, DP, Desmoplakin I, DPI, Desmoplakin (DPI, DPII), KPPS2, PPKS2, Desmoplakin, DPII |
Target Sequences: | NM_004415 NP_004406.2 P15924 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.