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DSG3 / Desmoglein 3

desmoglein 3

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.

Gene Name: desmoglein 3
Family/Subfamily: Cadherin , not assigned-Cadherin
Synonyms: DSG3, Balding, BAL, Cadherin family member 6, CDHF6, Desmoglein 3, Pemphigus vulgaris antigen, Desmoglein-3, PVA
Target Sequences: NM_001944 NP_001935.2 P32926

Publications (9)

1
Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris. Proby CM, Ota T, Suzuki H, Koyasu S, Gamou S, Shimizu N, Wahl JK, Wheelock MJ, Nishikawa T, Amagai M. The British journal of dermatology. 2000 142:321-30. (WB) [PubMed:10730768]
2
Protection against pemphigus foliaceus by desmoglein 3 in neonates. Wu H, Wang ZH, Yan A, Lyle S, Fakharzadeh S, Wahl JK, Wheelock MJ, Ishikawa H, Uitto J, Amagai M, Stanley JR. The New England journal of medicine. 2000 343:31-5. (ICC) [PubMed:10882766]
3
The fate of desmosomal proteins in apoptotic cells. Weiske J, Schneberg T, Schrder W, Hatzfeld M, Tauber R, Huber O. The Journal of biological chemistry. 2001 276:41175-81. (ICC, WB, IP) [PubMed:11500511]
4
Generation of monoclonal antibodies specific for desmoglein family members. Wahl JK. Hybridoma and hybridomics. 2002 21:37-44. (ICC, WB, IP) [PubMed:11991815]
5
Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation. Wu H, Stanley JR, Cotsarelis G. The Journal of investigative dermatology. 2003 120:1052-7. [PubMed:12787134]
6
Epitope definition by proteomic similarity analysis: identification of the linear determinant of the anti-Dsg3 MAb 5H10. Lucchese A, Mittelman A, Lin MS, Kanduc D, Sinha AA. Journal of translational medicine. 2004 2:43. [PubMed:15588331] [PMC:PMC544587]
7
Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases. Mahoney MG, Hu Y, Brennan D, Bazzi H, Christiano AM, Wahl JK. Experimental dermatology. 2006 15:101-9. (WB, IP) [PubMed:16433681]
8
Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. Tsang SM, Liu L, Teh MT, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F, Wan H. PloS one. 2010 5:e14211. (ICC) [PubMed:21151980] [PMC:PMC2997060]
9
Clinicopathological features of thymic carcinomas and the impact of histopathological agreement on prognostical studies. Weihofen A, Ostaszewski B, Minami Y, Selkoe DJ. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2012 (IHC; Human) [PubMed:23086701]
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Proteins (7)
Recombinant (7)
DSG3 / Desmoglein 3 (7)
No (7)
6His, N-terminus (2)
6His-SUMO, N-terminus (2)
His-GST (1)
His-SUMO (2)
Human (5)
Mouse (2)
E. coli (6)
Yeast (1)
Purified (4)
DSG3 / Desmoglein 3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
67.0 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
E. coli
His-SUMO
78.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
DSG3 / Desmoglein 3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
DSG3 / Desmoglein 3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
E. coli
His-SUMO
64 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
DSG3 / Desmoglein 3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
DSG3 / Desmoglein 3 Protein - Recombinant Desmoglein 3 By SDS-PAGE
Select
E. coli
His-GST
46.6 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).