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DRD2 / Dopamine Receptor D2

dopamine receptor D2

DRD2 / Dopamine Receptor D2 is the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.

Gene Name: dopamine receptor D2
Family/Subfamily: GPCR , Dopamine
Synonyms: DRD2, D2R, D(2) dopamine receptor, D2DR
Target Sequences: NM_000795 NP_000786.1 P14416

Publications (2)

1
Dopamine synthesis and dopamine receptor expression are disturbed in recurrent miscarriages. Gratz MJ, Stavrou S, Kuhn C, Hofmann S, Hermelink K, Heidegger H, Hutter S, Mayr D, Mahner S, Jeschke U, Vattai A. Endocrine connections. 2018 May;7:727-738. (Human) [Full Text Article] [PubMed:29686031] [PMC:PMC5958746] Related Antibodies: LS-A1403.
2
Expression of dopaminergic receptors on human CD4+ T lymphocytes: flow cytometric analysis of naive and memory subsets and relevance for the neuroimmunology of neurodegenerative disease. Kustrimovic N, Rasini E, Legnaro M, Marino F, Cosentino M. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2014 Jun;9:302-12. [Full Text Article] [PubMed:24682738] Related Antibodies: LS-C22924.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
DRD2 / Dopamine Receptor D2 (5)
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GST, N-terminus (1)
His-GST, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (3)
Rat (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (1)
DRD2 / Dopamine Receptor D2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
DRD2 / Dopamine Receptor D2 Protein - Recombinant Dopamine Receptor D2 By SDS-PAGE
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E. coli
His-T7
30.0 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
DRD2 / Dopamine Receptor D2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
47.2 kDa
20 µg/$150
DRD2 / Dopamine Receptor D2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
47.2 kDa
100 µg/$494
DRD2 / Dopamine Receptor D2 Protein - Recombinant Dopamine Receptor D2 (DRD2) by SDS-PAGE
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E. coli
His-GST, N-terminus
51kDa
10 µg/$287; 50 µg/$482; 200 µg/$962; 100 µg/$770; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).