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DPYSL2 / CRMP2

dihydropyrimidinase-like 2

DPYSL2 / CRMP2 is a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene Name: dihydropyrimidinase-like 2
Synonyms: DPYSL2, CRMP2, CRMP-2, DHPRP2, Dihydropyrimidinase-like 2, DRP-2, N2A3, ULIP2, ULIP-2, Unc-33-like phosphoprotein 2
Target Sequences: NM_001386 NP_001377.1 Q16555

Publications (4)

1
Glyoxalase 1-knockdown in human aortic endothelial cells - effect on the proteome and endothelial function estimates. Stratmann B, Engelbrecht B, Espelage BC, Klusmeier N, Tiemann J, Gawlowski T, Mattern Y, Eisenacher M, Meyer HE, Rabbani N, Thornalley PJ, Tschoepe D, Poschmann G, Stühler K. Scientific reports. 2016 6:37737. (WB; Human) [Full Text Article] [PubMed:27898103] [PMC:PMC5127188] Related Antibodies: LS-B3616.
2
Discovery of new membrane-associated proteins overexpressed in small-cell lung cancer. Sebahat Ocak, David B Friedman, Heidi Chen, Jamie A Ausborn, Mohamed Hassanein, Bruno Detry, Birgit Weynand, Frank Aboubakar, Charles Pilette, Yves Sibille, Pierre P Massion. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2014 March;9:324-36. [Full Text Article] [PubMed:24518087] [PMC:PMC4028683] Related Antibodies: LS-C198892.
3
The enhancement of CCL2 and CCL5 by human bone marrow-derived mesenchymal stem/stromal cells might contribute to inflammatory suppression and axonal extension after spinal cord injury. Kazumichi Yagura, Hirokazu Ohtaki, Tomomi Tsumuraya, Atsushi Sato, Kazuyuki Miyamoto, Naoto Kawada, Keisuke Suzuki, Motoyasu Nakamura, Koji Kanzaki, Kenji Dohi, Masahiko Izumizaki, Yutaka Hiraizumi, Kazuho Honda. PloS one. 2020 Mar;15:e0230080. [Full Text Article] [PubMed:32155215] [PMC:PMC7064230] Related Antibodies: LS-B5657.
4
PACAP stimulates functional recovery after spinal cord injury through axonal regeneration. Tsuchida M, Nakamachi T, Sugiyama K, Tsuchikawa D, Watanabe J, Hori M, Yoshikawa A, Imai N, Kagami N, Matkovits A, Atsumi T, Shioda S. Journal of molecular neuroscience : MN. Nov;54:380-7. [Full Text Article] [PubMed:25074795] Related Antibodies: LS-B5657.
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Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
DPYSL2 / CRMP2 (8)
No (8)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (5)
Human (6)
293T Cells (2)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Yeast (1)
Purified (1)
DPYSL2 / CRMP2 Protein
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Yeast
6His, N-terminus
64.3 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
DPYSL2 / CRMP2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
DPYSL2 / CRMP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
74 kDa
20 µg/$215
DPYSL2 / CRMP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
62.3 kDa
20 µg/$150
DPYSL2 / CRMP2 Protein - Purified recombinant protein DPYSL2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
62.1 kDa
20 µg/$1,107
DPYSL2 / CRMP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
62.3 kDa
100 µg/$494
DPYSL2 / CRMP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
74 kDa
100 µg/$710
DPYSL2 / CRMP2 Protein - 12.5% SDS-PAGE of human DPYSL2 stained with Coomassie Blue
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Wheat Germ Extract
GST
88.7 kDa
10 µg/$479; 25 µg/$670
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).