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Dihydropyrimidine dehydrogenase (DPYD) is a pyrimidine catabolic enzyme and the initial and rate-limiting step in the pathway of uracil and thymidine catabolism and also in the pathway leading to the formation of beta-alanine. The DPYD gene is a large gene of approximately 150 kb consisting of 23 exons encoding a protein of approximately 111-kD. Genetic deficiency of DPYD enzyme results in an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-flourouracil chemotherapy.
Gene Name: | dihydropyrimidine dehydrogenase |
Synonyms: | DPYD, Dihydrouracil dehydrogenase, DPD, Dihydrothymine dehydrogenase, DHP, DHPDHASE |
Target Sequences: | NM_000110 NP_000101.2 Q12882 |
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