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DPP6 / Dipeptidylpeptidase 6 is a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants.
Gene Name: | dipeptidyl-peptidase 6 |
Family/Subfamily: | Protease , Serine S9B |
Synonyms: | DPP6, Dipeptidylpeptidase VI, Dipeptidyl peptidase 6, Dipeptidyl peptidase VI, Dipeptidyl-peptidase 6, Dipeptidylpeptidase 6, DPP VI, DPPX, VF2, Dipeptidyl aminopeptidase-like protein 6 |
Target Sequences: | NM_001936 P42658 P42658 |
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