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DPP4 / CD26

dipeptidyl-peptidase 4

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

Gene Name: dipeptidyl-peptidase 4
Family/Subfamily: Protease , Serine S9B
Synonyms: DPP4, ADCP-2, ADABP, Dipeptidyl peptidase IV, Dipeptidyl-peptidase 4, DPPIV, ADCP2, T-cell activation antigen CD26, CD26, CD26 antigen, Dipeptidyl peptidase 4, Dipeptidylpeptidase 4, DPP IV, TP103
Target Sequences: NM_001935 NP_001926.2 P27487

Publications (2)

1
Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Park JW, Lee JK, Phillips JW, Huang P, Cheng D, Huang J, Witte ON. Proceedings of the National Academy of Sciences of the United States of America. 2016 113:4482-7. (WB; Rat) [Full Text Article] [PubMed:27044116] [PMC:PMC4843433]
2
Overexpression of CD26/DPPIV in mesothelioma tissue and mesothelioma cell lines. Amatya VJ, Takeshima Y, Kushitani K, Yamada T, Morimoto C, Inai K. Oncology reports. 2011 26:1369-75. (IHC-P; Human) [Full Text Article] [PubMed:21894438] Related Antibodies: LS-A8060.

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Products
ELISA Kits (31)
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DPP4 / CD26 (31)
Human (9)
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Rat (7)
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Monkey (1)
Pig (1)
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Coronavirus Detection (31)
ELISA Kits for Associated Targets (31)
12 x 8-Well Microstrips (3)
96-Well Microplate (6)
96-Well Strip Plate (22)
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Cell Culture Supernatants (6)
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Plasma (24)
Saliva (1)
Serum (24)
Tissue Homogenates (6)
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DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.63 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Microplate
Human
25 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Microplate
Human
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Saliva, Serum, Urine
1 Plate/$699
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.41 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
DPP4 / CD26 ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
32 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
DPP4 / CD26 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
125 - 8000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
DPP4 / CD26 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
78.125 - 5000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$822
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,018
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
DPP4 / CD26 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
DPP4 / CD26 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
DPP4 / CD26 ELISA Kit
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Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).