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DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation.
Gene Name: | docking protein 2, 56kDa |
Synonyms: | DOK2, Docking protein 2, 56kD, Dok-2, Docking protein 2, Docking protein 2, 56kDa, p56(dok-2), p56dok-2, p56DOK |
Target Sequences: | NM_003974 NP_003965.2 O60496 |
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