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Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
Gene Name: | dedicator of cytokinesis 1 |
Synonyms: | DOCK1, Dedicator of cytokinesis 1, Dedicator of cyto-kinesis 1, DOwnstream of CrK, Ced5, DOCK180 |
Target Sequences: | NM_001380 NP_001371.1 Q14185 |
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