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DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.
| Gene Name: | DNA (cytosine-5-)-methyltransferase 3 beta |
| Family/Subfamily: | C5-methyltransferase |
| Synonyms: | DNMT3B, DNA MTase HsaIIIB, ICF, ICF1, M.HsaIIIB, DNA methyltransferase HsaIIIB |
| Target Sequences: | NM_006892 NP_008823.1 Q9UBC3 |
Publications (12)
1
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B. Nature. 2002 416:552-6. (WB; Human)
[PubMed:11932749]
2
Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells. Weisenberger DJ, Velicescu M, Preciado-Lopez MA, Gonzales FA, Tsai YC, Liang G, Jones PA. Gene. 2002 298:91-9. (Mouse, Human)
[PubMed:12406579]
3
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A, MacLeod AR. Nature genetics. 2003 33:61-5. (WB; Human)
[PubMed:12496760]
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Publications
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(41)
Yes
(2)
DNMT3B Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
DNMT3B Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
DNMT3B Rabbit anti-Human Polyclonal (aa647-696) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
DNMT3B Mouse anti-Human Monoclonal (2280C3a) Antibody
Mouse, Rat, Human
DB, Flo, ICC, IF, WB
Unconjugated
100 µg/$486
DNMT3B Rabbit anti-Human Polyclonal (aa7-56) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
DNMT3B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
DNMT3B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
DNMT3B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
DNMT3B Rabbit anti-Human Polyclonal (1-80 aa, N-terminal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
DNMT3B Rabbit anti-Human Polyclonal (His7) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
DNMT3B Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
DNMT3B Rabbit anti-Human Polyclonal (aa389-417) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
DNMT3B Rabbit anti-Human Polyclonal (aa389-417) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
DNMT3B Rabbit anti-Human Polyclonal (aa389-417) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
DNMT3B Rabbit anti-Human Polyclonal (aa389-417) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
DNMT3B Rabbit anti-Human Polyclonal (aa389-417) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
DNMT3B Rabbit anti-Human Polyclonal (aa389-417) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
DNMT3B Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
DNMT3B Mouse anti-Human Monoclonal (7E5E9C1) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
DNMT3B Mouse anti-Human Monoclonal (4D1A2E5) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
DNMT3B Rabbit anti-Human Polyclonal (aa389-417) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
DNMT3B Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
0.1 mg/$394
DNMT3B Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$786
DNMT3B Rabbit anti-Mouse Polyclonal (aa581-859) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
DNMT3B Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$356; 100 µl/$461
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