Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Gene Name:
DNA (cytosine-5-)-methyltransferase 3 alpha
Synonyms:
DNMT3A, DNA MTase HsaIIIA, DNMT3A2, DNA methyltransferase HsaIIIA, M.HsaIIIA
An essential role for DNA methyltransferase DNMT3B in cancer cell survival. Beaulieu N, Morin S, Chute IC, Robert MF, Nguyen H, MacLeod AR. The Journal of biological chemistry. 2002 277:28176-81. (WB; Human)
[PubMed:12015329]
2
Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells. Weisenberger DJ, Velicescu M, Preciado-Lopez MA, Gonzales FA, Tsai YC, Liang G, Jones PA. Gene. 2002 298:91-9. (Mouse, Human)
[PubMed:12406579]
3
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A, MacLeod AR. Nature genetics. 2003 33:61-5. (WB; Human)
[PubMed:12496760]
4
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD. The Journal of biological chemistry. 2006 281:24790-802.
[PubMed:16766534]
5
SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma. Shikauchi Y, Saiura A, Kubo T, Niwa Y, Yamamoto J, Murase Y, Yoshikawa H. Molecular and cellular biology. 2009 29:1944-58.
[PubMed:19139273]
[PMC:PMC2655625]
6
Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL. Kaminskyy VO, Surova OV, Vaculova A, Zhivotovsky B. Carcinogenesis. 2011 32:1450-8.
[PubMed:21771726]
7
Epigenetic regulation of motor neuron cell death through DNA methylation. Chestnut BA, Chang Q, Price A, Lesuisse C, Wong M, Martin LJ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:16619-36.
[PubMed:22090490]
[PMC:PMC3238138]
Related Antibodies: LS-C96546.
8
Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases. Selvakumar T, Gjidoda A, Hovde SL, Henry RW. The Journal of biological chemistry. 2012 287:7039-50. (WB; Human)
[PubMed:22219193]
[PMC:PMC3293528]
9
Hiwi mediated tumorigenesis is associated with DNA hypermethylation. Siddiqi S, Terry M, Matushansky I. PloS one. 2012 7:e33711.
[PubMed:22438986]
[PMC:PMC3306289]
Related Antibodies: LS-C96545.
10
DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism. Shen J, Wang C, Li D, Xu T, Myers J, Ashton JM, Wang T, Zuscik MJ, McAlinden A, O'Keefe RJ. JCI insight. 2017 2: (WB; Human)[Full Text Article]
[PubMed:28614801]
[PMC:PMC5470890]
11
Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma. Lee HG, Kim H, Son T, Jeong Y, Kim SU, Dong SM, Park YN, Lee JD, Lee JM, Park JH. Oncotarget. 2016 July;7:41798-41810. (Human)[Full Text Article]
[PubMed:27260001]
[PMC:PMC5173097]
Related Antibodies: LS-C167495.
12
Black raspberries demethylate Sfrp4, a WNT pathway antagonist, in rat esophageal squamous cell papilloma. Yi-Wen Huang, Fei Gu, Alan Dombkowski, Li-Shu Wang, Gary D Stoner. Molecular carcinogenesis. 2016 November;55:1867-1875. [Full Text Article]
[PubMed:27696538]
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).